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Full publication list on Google Scholar


Pandey. D., Harris., M. H., Garud, N., Narasimhan, V. M., Understanding natural selection in Holocene Europe using multi-locus genotype identity scans, bioRxiv, 2022.11.30.518528. DOI: 10.1101/2023.04.24.538113

Flynn, B.I., Javan, E.M., Lin, E., Trutner, Z., Koenig, K., Anighoro, K. O., Kun, E., Gupta, A., Singh, T., Jayakumar, P., Narasimhan, V.M., Deep learning based phenotyping of medical images improves power for gene discovery of complex disease, in-press: medRxiv, 2023.03.06.5300086. DOI: 10.1101/2023.03.07.23286909

Zhou, A., Mihelic, S., Engelman, S., Tomar, A., Dunn, A. K., Narasimhan, V. M., A deep learning approach for improving two-photon vascular imaging speeds, bioRxiv2022.11.30.518528 (Paper, doi: 10.1101/2022.11.30.518528) 

Le, M.
, Smith, O., Akbari, A., Harpak, A., Reich, D., Narasimhan, V. M., 1,000 ancient genomes uncover 10,000 years of natural selection in Europe. bioRxiv, 2022.08.24.505188 (Paper, doi: 10.1101/2022.08.24.505188)


Kun, E., Javan, E. M., Smith, O., Gulamali, F., de la Fuente, J., Flynn, B., Vajrala, K., Trutner, Z., Jayakumar, P., Tucker-Drob, E. M., Sohail, M., Singh, T., Narasimhan, V. M., The genetic architecture and evolution of the human skeletal form. Science, 2023.01.03.521284 (Paper, doi: 10.1101/2023.01.03.521284) - cover article in Science Magazine

Kun, E.Narasimhan, V. M., Fast-evolving genomic regions underlie human brain development. Nature614, 37-38 (Paper, doi: 10.1038/d41586-023-00069-2)

Scott, C., Cárdenas, A., Mah M., Narasimhan, V. M., Rohland, N., Toth, L., Voolstra, C., Reich, D., Matz, M, Millennia-old coral holobiont DNA provides insight into future adaptive trajectories, Molecular Ecology. 2022; 31:4979-4990; (Paper, Supplementary Materials, doi: 10.1111/mec.16642)

Yan, J., Patterson, N., Narasimhan, V. M., miqoGraph: Fitting admixture graphs using mixed-integer quadratic optimization. Bioinformatics. btaa988; (Paper, Supplementary Materials, doi: 10.1093/bioinformatics/btaa988)

Cuvertino, S., Hartill, V., (12 other authors), Narasimhan, V. M.*, et al. A restricted spectrum of missense KMT2D variants cause a multiple malformations disorder distinct from Kabuki syndrome. Genetics in Medicine. 22:867-877; (Paper, Supplementary Materialsdoi: 10.1038/s41436-019-0743-3)

Narasimhan, V. M.*, Patterson, N. J.*, et al. The Formation of Human Populations in South and Central Asia; Science. 365:eaat7487; (PaperSupplementary MaterialsGenotype dataOnline Data Visualizer, doi: 10.1126/science.aat7487)  - the most widely accessed genetics/genomics paper in the history of the bioRxiv pre-print server.

Narasimhan, V. M.*, Rohland, N., An Ancient Harappan Genome Lacks Ancestry from Steppe Pastoralists or Iranian Farmers. Cell. 179:1–7; (PaperGenotype dataOnline Data Visualizer, doi: 10.1016/j.cell.2019.08.048)

Hajdinjak, M., Fu, Q., Hübner, A., (4 other authors), Narasimhan, V. M., et al. Reconstructing the genetic history of late Neanderthals. Nature. 555, 652–656; (PaperSupplementary Materialsdoi: 10.1038/nature26151)

Xue, Y., Mezzavilla, M., Haber, M., McCarthy, S., Chen, Y., Narasimhan, V. M., et al. Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations. Nature Communications. 8, 15927; (Paper, Supplementary Materials, doi: 10.1038/ncomms15927)

Narasimhan, V. M., Rahbari, R., Scally, A., Wuster, A., Mason, D., Xue, Y., Wright, J., Trembath, R. C., Maher, E. R., van Heel, D. A., Auton, A., Hurles, M. E., Tyler-Smith, C. & Durbin, R. Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes. Nature Communications. 8, 303; (Paper, Supplementary Materials, doi: 10.1038/s41467-017-00323-y)

Narasimhan, V. M., Danecek, P., Scally, A., Xue, Y., Tyler-Smith, C. & Durbin, R. BCFtools/RoH: a hidden Markov model approach for detecting autozygosity from next-generation sequencing data. Bioinformatics. 32, 1749–51. (Paper, Supplementary Materials, doi: 10.1093/bioinformatics/btw044

Chappell, J., Harman, J. L., Narasimhan, V. M., et al. Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models. Circulation Research. 119, 1313–1323 (2016). (Paper, Supplementary Materials, doi: 10.1161/CIRCRESAHA.116.309799)

Narasimhan, V. M., Hunt, K. A., Mason, D., et al. Health and population effects of rare gene knockouts in adult humans with related parents. Science. 352:474-77; (PaperSupplementary Materials, doi: 10.1126/science.aac8624)

Narasimhan, V. M., Xue, Y. & Tyler-Smith, C. Human Knockout Carriers: Dead, Diseased, Healthy, or Improved? Trends in Molecular Medicine. 22, 341-51. (Paper, doi: 10.1016/j.molmed.2016.02.006)

Xue Y*, Prado-Martinez J*, Sudmant PH*, Narasimhan, V. M.*, et al. Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding. Science. 348 (6231) :242-5. (PaperSupplementary Materials, doi: 10.1126/science.aaa3952)

Pelle, K. G., Oh, K., Buchholz, K., Narasimhan, V. M., Joice, R., Milner, D. A., Brancucci, N., Ma, S., Voss, T. S., Ketman, K., Seydel, K. B., Taylor, T. E., Barteneva, N. S., Huttenhower, C. & Marti, M. Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection. Genome Medicine. 7, 19. (Paper, Supplementary Materials, doi: 10.1186/s13073-015-0133-7)

Joice, R.*, Narasimhan, V. M.*, Montgomery, J., Sidhu, A. B., Oh, K., Meyer, E., Pierre-Louis, W., Seydel, K., Milner, D., Williamson, K., Wiegand, R., Ndiaye, D., Daily, J., Wirth, D., Taylor, T., Huttenhower, C. & Marti, M. Inferring Developmental Stage Composition from Gene Expression in Human Malaria. PLoS Computational Biology. 9, e1003392. (Paper, Supplementary Materials, doi: 10.1371/journal.pcbi.1003392)

Segata, N., Waldron, L., Ballarini, A., Narasimhan, V. M., Jousson, O. & Huttenhower, C. Metagenomic microbial community profiling using unique clade-specific marker genes. Nature Methods. 9, 1–7. (Paper, Supplemetary Materials, doi: 10.1038/nmeth.2066)
































































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